This is an original autograph and not a copy.
Since 1996, Myles has appeared in a number of American and British films and television productions. In 2001, she got a small role alongside Johnny Depp as his on-screen wife, Victoria Abberline, in the thriller film From Hell. She had a supporting role in the 2003 film Underworld and its sequel Underworld: Evolution (in a brief flashback scene). In 2003, she played the schoolgirl lead in the thriller Out of Bounds and she also played Lady Penelope in the Thunderbirds. In 2006, Myles co-starred with actor James Franco in the romantic drama Tristan and Isolde, playing the role of Isolde.
Myles appeared as Madame de Pompadour in a 2006 episode of Doctor Who, "The Girl in the Fireplace"; the episode was nominated for a Nebula Award and won the 2007 Hugo Award for Best Dramatic Presentation, Short Form. She co-starred opposite Max Minghella, playing his love interest in 2006's quirky comedy film Art School Confidential. Also in 2006, Myles appeared in a BBC TV adaptation of Dracula; she played Lucy Westenra alongside Marc Warren, David Suchet and Dan Stevens. As of 2007, she filmed Outlander with James Caviezel and Jack Huston, playing the role of Freya.
She was cast in the CBS supernatural television drama, Moonlight. She has received Best Actress in 2007 for her role in Hallam Foe from the British Independent Film Award committee as well as the BAFTA Scotland Award. Her series, Moonlight, won for Best New Drama in the 2007 People's Choice Awards.
In 2010 Myles joined Spooks— the BBC series about a counter-terrorism unit in MI5—for its ninth series playing Beth Bailey alongside fellow newcomer Max Brown.