Nik Howden from Vincent & The Doctor signed 10 by 8 photograph
The Doctor has taken Amy to the Musée d'Orsay in Paris, where they admire the work of the post-impressionist painter Vincent van Gogh. The Doctor discovers a seemingly alien figure in a window of the painting The Church at Auvers, and decides they must travel back in time to speak to Vincent. In 1890, they find Vincent at a cafe in Arles, a lonely man with a bad reputation, but who opens up when he notices Amy. They discover that recent deaths, victims ravaged by some type of beast, have been blamed on Vincent, and the two resolve to help him.
The Doctor and Amy stay at Vincent's home overnight, where he confesses his belief that his works have little value to anyone but himself, but still he believes the universe is filled with more wonders than one could imagine. When Amy is attacked by an invisible beast that only Vincent can see, Vincent paints an image for the Doctor, who identifies it as a Krafayis, a vicious pack-predator that has been abandoned on Earth. The three prepare to depart to stop the creature, the Doctor promising that after they have dealt with it, the Doctor and Amy will be out of Vincent's way; this causes Vincent to break down into tears and shuts himself in his bedroom. When the Doctor approaches him, Vincent says that everyone leaves him in the end, forgotten and hopeless. The Doctor attempts to empathise with him, but Vincent becomes upset and orders him to go. As the Doctor and Amy leave to face the creature on their own, Vincent reappears, determined to assist them. As they leave towards the church, Vincent confides in Amy that if she can "soldier on, then so can Vincent van Gogh", aware of a sadness and loss within Amy that she cannot detect herself.
At the church, Vincent begins to paint the church watching for the beast to appear. Several hours pass before he spots it, and the Doctor proceeds inside on his own, warning Amy and Vincent to stay outside, and hoping to stun the creature with his sonic screwdriver. Amy resolves to follow the Doctor, and when she does, Vincent follows her. Vincent catches sight of the beast stalking the Doctor, and warns him in time, sending the Doctor and Amy into hiding inside a confessional. Through Vincent's descriptions of the Krafayis' actions, the Doctor realises the creature is blind, and thus why it was left behind by its pack. Vincent attempts to defend himself from the creature with his easel, but the creature ends up impaling himself on it. The Doctor attempts to sooth the creature as it dies, while Vincent is able to explain its actions as from fear and frustration at its lack of sight, empathising with the Krafayis's pain as similar to his own.
Outside, the three rest on the grass, and Vincent explains how he sees the night sky, deep blue, framed by swirling air, and the Doctor recognizes the inspiration of Vincent's works. The next day, the Doctor and Amy prepare to leave, and Vincent tells Amy that if she should ever leave the Doctor, to return and marry him. The Doctor offers to show Vincent something, and takes him in the TARDIS back to Musée d'Orsay in 2010. There, the Doctor initiates a discussion with an art historian, Dr. Black, within earshot of Vincent; Dr. Black gushes about Vincent's work, referring to him as "the greatest painter of them all". Overjoyed at hearing this, Vincent hugs Dr. Black and kisses his cheeks in gratitude. The three return to the past, where the Doctor and Amy say their final goodbyes to Vincent, now a changed man. Again Amy politely declines Vincent's marriage proposal, saying she's "not really the marrying kind".
As they return to 2010, Amy hopes they have influenced Vincent to live a long life and paint many more works. However, back at the Musée d'Orsay, she finds that Vincent still committed suicide at 37. The Doctor explains that life is a mixture of bad and good, and while their brief encounter with Vincent couldn't undo everything wrong, they added some good to his life, as evident in subtle changes in the displayed works: the face no longer appears in The Church, and now, Vase with 12 Sunflowers bears the inscription, "For Amy".