In 1974, Goldblum appeared in Death Wish as Freak # 1. Later in his career, as "Lacey Party Guest" in Annie Hall (1977), Goldblum is seen saying into the telephone at a Hollywood party, "I forgot my mantra." Goldblum has had leading roles in films such as The Fly, Independence Day, The Lost World (1997), Earth Girls Are Easy, The Tall Guy, and Vibes (1988). Goldblum's strong supporting roles include those in Invasion of the Body Snatchers (1978), The Big Chill (1983), Into the Night (1985), Jurassic Park (1993), and he also had strong supporting roles in The Life Aquatic with Steve Zissou (2004) and the cult films The Adventures of Buckaroo Banzai Across the Eighth Dimension (1984) and Igby Goes Down (2002).
For several years, Goldblum was the voice for most U.S. Apple commercials, including advertisements for the iMac and iBook. He also voices some U.S. Toyota commercials as well as Procter & Gamble's facial cream line. He has recently appeared on Irish TV in commercials for the National Lottery.
Goldblum taught acting at Playhouse West in North Hollywood with Robert Carnegie. It was with several actors from this acting company that he improvised and directed the live action short film Little Surprises, which was nominated for an Academy Award in 1996.
Goldblum got the role of Adam in the upcoming film Adam Resurrected, a film adaptation of the Yoram Kaniuk novel. Jeff is a German entertainer who becomes the ringleader to a group of Holocaust survivors in an asylum after World War II.
In September 2006, it was announced that Goldblum was one of the founding members of a new theater company in New York called The Fire Dept. According to press materials, "The Fire Dept is made up of established and emerging writers, directors, actors and designers who have come together to create and produce work that cannot be replicated inside a television box or on a movie screen...The work of The Fire Dept combines the rigor and structure of great narrative storytelling with the vitality of formal experimentation to immerse audiences in a total experience that leaves them awake, alive and transformed." The company will devote energy into developing new live theater works as well as interpreting old favorites.
His guest appearance was on Sesame Street in 1990 as Bob's long-lost brother Minneapolis (parody of Indiana Jones) where Big Bird's friend Snuffleupagus had "the golden cabbage of Snuffertiti" hidden in his cave. He has also appeared on Tom Goes to the Mayor, The Colbert Report, and Tim and Eric Awesome Show Great Job!.
Goldblum replaced Chris Noth as a Senior Detective on Law & Order: Criminal Intent. In the series, Goldblum plays the role of Detective Zach Nichols. In August 2010, media outlets reported that Goldblum had decided not to return to Criminal Intent due to persistent concerns about the program's future