nominated for a London Evening Standard Theatre Award for Best Actress (for playing Elena in Chekhov's Uncle Vanya at the Donmar Warehouse). She was later nominated for a 2006 Laurence Olivier Theatre Award for her role as Rosalind in As You Like It, in London's West End. In April, 2008, she made a "compelling" Rebecca West in a production of Ibsen's Rosmersholm at the Almeida Theatre, London.
She appeared in Charles II: The Power and The Passion (2003), as Barbara Villiers, Countess of Castlemaine, and in supporting roles in such films as Interview with the Vampire (1994), Charlotte Gray (2001), The Count of Monte Cristo (2002), and Casanova (2005). In The Queen (2006) she played Cherie Blair, a role she reprised in Peter Morgan's follow up, The Special Relationship.
She appeared in a modernised TV adaptation of Frankenstein's Monster, simply called Frankenstein. Her first pregnancy forced her to pull out of Harry Potter and the Order of the Phoenix (2007), in which she had been cast as Bellatrix Lestrange. (She was replaced by Helena Bonham Carter.) However, McCrory later played Bellatrix's sister Narcissa Malfoy in Harry Potter and the Half-Blood Prince, released in July 2009. McCrory also reprised her role in the final movies, Harry Potter and the Deathly Hallows – Part 1 and Part 2. She also played Rosanna Calvierri in the episode "The Vampires of Venice" of the BBC television show, Doctor Who.
McCrory will appear in The Last of the Haussmans at the Royal National Theatre beginning 12 June 2012. The production will be broadcast to cinemas around the world on 11 October 2012 through the National Theatre Live programme