portrayed the Bajoran Leeta on Star Trek: Deep Space Nine for five years, from 1995 to 1999, and Ivy Lief on General Hospital. Her recent prominent feature film roles include starring as a sultry singer in James Kerwin's sci-fi film noir Yesterday Was a Lie, which she also produced, and voicing "Janice Em" in the animated film Robotech: The Shadow Chronicles. Her television guest starring roles include ER and Sliders (as Kelly Welles, the sister of Wade Welles).
Masterson was named one of the world's "50 Sexiest Women" by the men's magazine Femme Fatales, and the "Favorite Science Fiction Actress on Television" in a TV Guide reader's poll. In December 2009, AOL named her one of the "Ten Sexiest Aliens on TV", reporting that "Masterson is regularly voted the most popular guest at Star Trek conventions."