made her professional debut on British television in 1979, and appeared in the television movie A Tale of Two Cities. She went on to play Sybil Gordon in Chariots of Fire and Eva Galli/Alma Mobley in Ghost Story, both in 1981.
She earned a Plays and Players Award, as well as a Laurence Olivier Award for Most Promising Newcomer, after appearing in a 1981 West End theatre production of George Bernard Shaw's Arms and the Man. This early theatrical success allowed her to also work with the Royal Shakespeare Company.
Krige played Bathsheba in King David (1985) and Mary Shelley in Haunted Summer (1988). She appeared on stage in plays such as Thomas Otway's Venice Preserv'd. She appeared in what she called "tons of TV" in both the United States and the United Kingdom, including made for television movies from Baja Oklahoma (1988) and Ladykiller (1992), to mini-series such as Ellis Island (1984) and Scarlet and Black (1993). She also performed in several horror films, including Ghost Story, Sleepwalkers, Stay Alive, and Silent Hill.
In Star Trek: First Contact, she played the Borg Queen, who attempts to assimilate Earth into the Borg collective. She won Best Supporting Actress at the 1997 Saturn Awards for that role. Krige returned to this character in the Star Trek game Star Trek: Armada II and in the Star Trek: Voyager series finale "Endgame" in 2001.